Question

1. What is the significance of detecting cells in CSF count. What are the normal and abnormal findings of a normal CSF ?...


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Transcribed: 1. What is the significance of detecting cells in CSF count. What are the normal and abnormal findings of a normal CSF ?

Answer

CSF, cerebrospinal fluid is presnt inside the ventricles of brain and in subarachnoid spaces of cranium and spine. Is a ultrafilterate of plasma. It performs the function like shock absprber, homeostatis, providing nutrition, immune function. 

The counting of CSF is done using hemocytometer chamber to find WBC/Nucleated cell counted and RBC counted. After that a smear is made and is stained. In this stained slide 100 cells are counted and differentiated into cell types.  

Significance

  1. To diagnose and detect organic central nervous system diseases. 
  2. Increased leucocytic count indicate meningeal irritation which can be aseptic or septic. 
  3. RBCs presence may result of subdural bleeds or bloody tap. 
  4. The cellular reaction of neutrophils and lymphocytes depends on nature and duration of disease like menngitis, CNS hemorrhage or meningoencephalitis. 

Normal findings include:

  1. No RBCs 
  2. WBCs adults = 0-5 mononuclear cells/uL
  3. WBCs adult = 40-80% lymphocytes                                                                                                                                                           15-45% monocytes                                                                                                                                                              0-6 % neutrophils

Abnormal findings 

  1. Presence of RBCs, indicate towards bleeding in CSF.
  2. Increse in WBCs because of inflammation or infection or encephalitis, hemorrhage, meningitis 
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