Question

Over time, cancer cells are known to produce weakly antigenic variants of cell surface proteins. This will result in ---...


Over time, cancer cells are known to produce weakly antigenic variants of cell surface proteins. This will result in ----.

  1. protection of cells from the immune system
  2. increase in cancer cell death by the immune system
  3. Neither A nor B. It will make no difference.

 

Therapeutic antibodies used in the treatment of cancer are targeted at proteins located

  1. On the cell surface of cancer cells. On the cell surface of normal cells.
  2. In the nucleus of cancer cells.
  3. In the cytoplasm of cancer cells.
  4.   C and D.

Answer

Tumour antigens are those that are displayed on the surface of tumour cells by MHC class I or II molecules. These antigens are occasionally only expressed by tumour cells and are never expressed by normal cells. Tumor-specific antigens (TSAs) are what they're termed in this circumstance, and they're usually the outcome of a tumor-specific mutation.

An antibody binds to a particular molecule (antigen) on a targeted cell's surface, such as a cancer cell. When an antibody attaches to a cell, it acts as a signal to recruit disease-fighting chemicals or as a trigger for other immune system activities to destroy the cell.

1. Option 2 is correct.

increase in cancer cell death by the immune system

2. Option 1 is correct.

On the cell surface of cancer cells. 

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